Call your doctor for medical advice about side effects.

Sildenafil citrate is a medication used primarily to treat erectile dysfunction.
It belongs to the class of drugs called phosphodiesterase type 5 inhibitors.
Sildenafil was originally developed to treat angina and hypertension.
The drug works by increasing blood flow to the penis during stimulation.
It is commonly sold under the brand name Viagra.
Sildenafil is available by prescription and as generics.
The typical dose is 50 mg taken about an hour before activity.
Common side effects include headaches, flushing, and nasal congestion.

You may report side effects to the FDA at 1-800-FDA-1088.

The discovery of sildenafil began with research on heart drugs.
It was found to cause vasodilation as a side effect.
Pfizer refined the drug for erectile dysfunction.
It became a blockbuster drug upon FDA approval.
Sildenafil has helped millions worldwide.
It has changed perceptions about male sexual health.
Ongoing research explores new formulations.
Awareness campaigns promote safe usage.

Introduction: Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.

7. Interactions

Check with your doctor immediately if any of the following side effects occur: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Aim: Assess the tolerability and efficacy of sildenafil initiated at the 100-mg dose in men with ED. Methods: Men with ED (score < or =25 on the Erectile Function domain of the International Index of Erectile Function) who had received < or =6 total doses of a phosphodiesterase type 5 inhibitor

Product	Dosage	Quantity + Bonus	Price
Kamagra Polo	100mg	84 + 4 Pills	244.49€ 232.85€
Kamagra Polo	100mg	20 Pills	83.56€ 79.58€
Viagra Generic	25mg	20 Pills	37.74€ 35.94€
Viagra Generic	25mg	180 + 6 Pills	154.93€ 147.55€
Kamagra	100mg	60 + 4 Pills	201.34€ 191.75€
Kamagra Soft Tabs	100mg	272 + 12 Pills	593.42€ 565.16€
Viagra Generic	25mg	60 + 4 Pills	71.99€ 68.56€
Viagra Generic	50mg	360 + 10 Pills	225.33€ 214.60€
Viagra Generic	100mg	90 + 6 Pills	129.02€ 122.88€
Viagra Generic	25mg	90 + 6 Pills	105.03€ 100.03€
Kamagra Soft Tabs	100mg	120 + 6 Pills	311.78€ 296.93€
Kamagra Polo	100mg	12 Pills	60.21€ 57.34€
Viagra Generic	200mg	120 + 8 Pills	204.80€ 195.05€
Kamagra	100mg	84 + 6 Pills	264.44€ 251.85€

and none within 4 weeks were randomized to 8 weeks of double-blind, placebo-controlled (DBPC), fixed-dose treatment (50 or 100 mg sildenafil or placebo) followed by 4 weeks of open-label flexible-dose sildenafil (50 or 100 mg).

Sildenafil works by inhibiting phosphodiesterase type 5 enzyme.
This inhibition increases cGMP levels in the body.
Elevated cGMP leads to smooth muscle relaxation.
It promotes vasodilation in the corpus cavernosum.
This process facilitates an erection during sexual activity.
The drug’s pharmacokinetics allow for rapid absorption.
Food intake can influence absorption rate.
It is effective in men of various ages.

Main outcome measures: Efficacy, tolerability, treatment satisfaction, and other end points were measured at baseline and/or the end of the double-blind and open-label phases and compared between placebo and sildenafil initiated at doses of 50 and 100 mg.

What to avoid

If you take too much sildenafil or take it together with these medicines, the chance for side effects will be higher. It is important to tell your doctor about any heart problems you have now or may have had in the past. This medicine can cause serious side effects in patients with heart problems. If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately. This condition may require prompt medical treatment to prevent serious and permanent damage to your penis.

Dysfonction érectile

If you experience a sudden loss of vision in one or both eyes, contact your doctor immediately. Check with your doctor right away if you have a sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears. If you already use medicine for high blood pressure (hypertension), sildenafil could make your blood pressure go too low. Call your doctor right away if you have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, sweating, or unusual tiredness or weakness. This medicine does not protect you against sexually transmitted diseases (including HIV or AIDS). Results: Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and 100 mg compared with placebo.

Parameter	Frequency	Purpose	Notes
Blood Pressure	Before and after dosage	Check for hypotension	Especially in high-risk groups
Visual Function	Periodic	Monitor for retinal issues	Baseline and follow-up
Liver Function Tests	As needed	Detect hepatotoxicity	For long-term users

At the end of DBPC treatment, 56% of men on the 100-mg dose felt no anxiety about the next intercourse attempt compared with 39% in the 50-mg group (odds ratio 2.03; P = 0.0197).

What special precautions should I follow?

However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use.

Dose pédiatrique

Store mixed oral liquid in the refrigerator. Throw away any unused mixed Revatio® oral liquid after 60 days. It is important that you tell all of your doctors that you take sildenafil. If you need emergency medical care for a heart problem, it is important that your doctor knows when you last took sildenafil. Do not use this medicine if you are also using a nitrate medicine, often used to treat angina or high blood pressure.

What should I know about sildenafil before taking it?

Some illegal ("street") drugs called "poppers" (such as amyl nitrate, butyl nitrate, or nitrite). Do not use this medicine if you also use riociguat (Adempas®). If you will be taking this medicine for pulmonary arterial hypertension, your doctor will want to check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. If you sildenafil premature ejaculation take sildenafil for pulmonary arterial hypertension, do not take Viagra®, Vibrique™ or other PDE5 inhibitors, including tadalafil (Cialis®) or vardenafil (Levitra®). Changes in functional scores from baseline were not statistically significant with the 100-mg dose compared with the 50-mg dose in the DBPC.

Side Effect	Frequency	Severity	Management Tips
Headache	Very common	Mild to moderate	Analgesics if needed
Flushing	Common	Mild	Cool environment, hydration
Dyspepsia	Common	Mild	Dietary adjustments
Nasal Congestion	Less common	Mild	Decongestants if necessary
Dizziness	Less common	Mild	Avoid sudden movements

Measures of treatment satisfaction and sexual experience significantly favored the 100-mg dose compared with the 50-mg dose in the DBPC.

Route of administration

The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For treatment of erectile dysfunction:For oral dosage form (tablets):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse.

How should Sildenafil Citrate Tablets be stored?

Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. Your doctor may adjust your dose if needed.Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose if needed.Children—Use is not recommended.For oral dosage form (film):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose as needed.Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose as needed.Children—Use is not recommended.

What should happen if a dose is missed?

For oral dosage form (tablets):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose if needed.Children—Use is not recommended. Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose if needed. Adults 65 years of age and older—25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. There was no increase in adverse events with the higher dose.

How should I take sildenafil?

For oral dosage form (film):Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Your doctor may adjust your dose as needed. For treatment of pulmonary arterial hypertension:For oral dosage forms (suspension or tablets):Adults—20 milligrams (mg) 3 times a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 80 mg 3 times a day.Children 1 year of age and older weighing 45 kilograms (kg) or more—20 mg 3 times a day.

Marketing and sales

However the dose is usually not more than 40 mg 3 times a day.Children 1 year of age and older weighing 20 to 45 kg—20 mg 3 times a day.Children 1 year of age and older weighing 20 kg or less—10 mg 3 times a day.Children younger than 1 year of age—Use and dose must be determined by your doctor. For oral dosage forms (suspension or tablets):Adults—20 milligrams (mg) 3 times a day. Adults—20 milligrams (mg) 3 times a day. However, the dose is usually not more than 80 mg 3 times a day. Children 1 year of age and older weighing 45 kilograms (kg) or more—20 mg 3 times a day.

Other warnings

However the dose is usually not more than 40 mg 3 times a day. Children 1 year of age and older weighing 20 to 45 kg—20 mg 3 times a day. Children 1 year of age and older weighing 20 kg or less—10 mg 3 times a day. Children younger than 1 year of age—Use and dose must be determined by your doctor. For oral dosage forms (suspension or tablets): If you miss a dose of this medicine, take it as soon as possible. Conclusions: Sildenafil at 50 mg or 100 mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC.

Non-medical use

Use protective measures and ask your doctor if you have any questions about this. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.