"Does marijuana use play a role in the recreational use of sildenafil?". Archived from the original on 26 January 2013. "Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America. "Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 14 August 2020. "Bears' Brandon Marshall says some NFL players use Viagra .. on the Field". Archived from the original on 5 March 2016. "Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction".
- First-line treatment: Usually oral PDE5 inhibitors due to efficacy and ease of use.
- Second-line treatment: Includes intracavernosal injections or intraurethral suppositories.
- Third-line treatment: Includes vacuum devices and surgical penile implants.
- Step-care model: Progressing from least invasive to more invasive treatments.
- Treatment goals: To achieve erections sufficient for satisfactory sexual intercourse.
- Success rates: Vary by treatment; PDE5 inhibitors work for about 60-80% of men.
- Treatment adherence: Side effects, cost, and psychological factors affect continued use.
- Combination approaches: Using psychological therapy alongside medical treatment.
- Follow-up care: Important to assess effectiveness and adjust treatment as needed.
- Treatment discontinuation: Reasons include cost, side effects, or loss of a partner.
Archived from the original on 4 March 2016.
Erectile Dysfunction Drugs Market Report Highlights
Archived from the original on 10 October 2020. "Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review". Archived from the original on 29 August 2021. "Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options". "Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis".
1. VED (Vacuum Erection Device)
"Interventions for preventing high altitude illness: Part 1. Archived from the original on 10 June 2017. ^ "FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems" (Press release). Archived from the original on 22 October 2016. "Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date". ^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. ^ "Hidden Risks of Erectile Dysfunction 'Treatments' Sold Online". Archived from the original on 23 April 2019. ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011. "Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist".
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Original | 100mg | 4 Pills | 40.94€ 38.99€ | |
| Cialis Generic | 5mg | 60 + 4 Pills | 86.02€ 81.92€ | |
| Levitra Generic | 60mg | 270 + 10 Pills | 714.53€ 680.50€ | |
| Viagra Original | 100mg | 8 Pills | 59.84€ 56.99€ | |
| Cialis Generic | 10mg | 270 + 10 Pills | 308.71€ 294.01€ | |
| Levitra Original | 20mg | 48 + 4 Pills | 235.14€ 223.94€ | |
| Levitra Generic | 40mg | 30 + 2 Pills | 93.58€ 89.12€ | |
| Kamagra Gold | 50 mg | 12 Pills | 47.30€ 45.05€ | |
| Cialis Soft Tabs | 20mg | 60 + 4 Pills | 159.37€ 151.78€ | |
| Levitra Generic | 10mg | 30 + 4 Pills | 62.39€ 59.42€ | |
| Kamagra Oral Jelly | 100 mg | 220 + 18 Sachets | 662.24€ 630.70€ |
^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived from the original on 14 January 2012.
- Amikacin: Aminoglycoside antibiotic for serious Gram-negative infections.
- Gentamicin: Treats septicemia, meningitis, and urinary tract infections.
- Tobramycin: Used for Pseudomonas infections, especially in CF patients.
- Streptomycin: An aminoglycoside for tuberculosis and plague.
- Neomycin: Topical and oral for bowel decontamination and skin infections.
- Kanamycin: Used for certain bacterial infections, often in combination therapy.
- Paromomycin: Treats intestinal parasitic infections like amoebiasis.
- Spectinomycin: Alternative treatment for gonorrhea.
- Amikacin: Potent against multidrug-resistant bacteria.
- Netilmicin: Broad-spectrum aminoglycoside for severe infections.
- Gentamicin (topical): Used for skin infections and wounds.
"Onset and duration of action of sildenafil for the treatment of erectile dysfunction". ^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond". Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra! ^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: increase libido in women an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction". "Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs". Archived from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef". Archived from the original on 1 November 2012. ^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture".
| Rank | Drug Name | Estimated Sales (USD Millions) | Market Share (%) |
|---|---|---|---|
| 1 | Sildenafil | 950 | 45 |
| 2 | Tadalafil | 700 | 33 |
| 3 | Vardenafil | 150 | 7 |
| 4 | Avanafil | 100 | 5 |
"A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009.
Preparing for your appointment
^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". "Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension". "Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions". Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association". Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021.
What special dietary instructions should I follow?
Archived from the original on 31 March 2021. Archived from the original on 12 August 2025. ^ "Sildenafil Drug Usage Statistics, United States, 2014 - 2023". "Generic Viagra: Two versions of sildenafil hit the market today". Archived from the original on 25 November 2018.
By Mode of Administration
Archived from the original on 12 February 2022. "With Viagra Now Available Over-The-Counter In The U.K., Will The U.S. "Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus". "Strategies for managing erection tablets sexual dysfunction induced by antidepressant medication". The Cochrane Database of Systematic Reviews (5) CD003382. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. ^ "Viagra to cenforce 100 soft go generic in 2017 according to Pfizer agreement".
Is It Safe To Switch Erectile Dysfunction Medications?
[125] By 2017, there were over 50 generic sildenafil pills available. During that year Viagra sales slumped to 38% that of Palpal. There were 2,958,199 prescriptions for Sildenafil in 2016 in England, compared with 1,042,431 in 2006. In 2018, Viagra Connect, a particular formulation of Sildenafil marketed by Pfizer, became available for sale without a prescription in the UK. Archived from the original on 12 October 2020.
Cost of erectile dysfunction pills
^ "Viagra 25mg film-coated tablets Summary of Product Characteristics (SmPC)". ^ "Viagra Connect 50 mg film-coated tablets Summary of Product Characteristics (SmPC)". Archived from the original on 13 August 2020. Archived from the original on 11 October 2020. Archived from the original on 11 November 2020. Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill". Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide".
- Penile Doppler ultrasound: Uses sound waves to visualize blood flow in the penis.
- Intracavernosal pharmacotesting: Injecting a drug to assess erectile response.
- Neurological testing: To assess nerve function if neurological ED is suspected.
- Hormonal panel: Tests for testosterone, prolactin, LH, FSH, and thyroid hormones.
- Vascular surgery: A rare option to repair specific arterial blockages causing ED.
- Venous ligation surgery: An older, largely abandoned surgery for venous leak.
- Acoustic wave therapy devices: For home use, though efficacy is less established.
- Red light therapy: Some devices claim to improve blood flow using specific wavelengths.
- Platelet-rich plasma (PRP) injections: An experimental treatment for ED.
- Low-intensity focused ultrasound: Another experimental modality for tissue regeneration.
Archived from the original on 10 January 2017.
Get a Personalized Treatment Plan to Help You Feel Your Best.
"Recreational use and misuse of phosphodiesterase 5 inhibitors". Archived from the original on 21 August 2016. "Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006). "The rise of Viagra among British illicit drug users: 5-year survey data". "Online pharmacies suspected of counterfeit drug sales".
Mechanism of action
^ Nichols DJ, Muirhead GJ, Harness JA (6 March 2002). "Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality". The American Society of Health-System Pharmacists. Archived from the original on 23 April 2020. PDE-5 inhibitors appear to have significant but moderate efficacy in secondary [Raynaud's phenomenon].
Focused shockwave therapy
"Sublingual sildenafil in the treatment of erectile dysfunction: faster onset of action with less dose". "The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction". ^ "Drug Approval Package: Viagra (sildenafil citrate) NDA #020895". U.S. Food and Drug Administration (FDA). ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says". ^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 October 2013. "Yes, There Is a Way to Get Generic Viagra".
| Drug Name | Absorption Time | Half-life | Metabolism Pathway |
|---|---|---|---|
| Sildenafil | 30-60 min | 4 hours | CYP3A4 |
| Tadalafil | 30-60 min | 17.5 hours | CYP3A4 |
| Vardenafil | 30-60 min | 4-5 hours | CYP3A4 |
| Avanafil | 15-30 min | 3-5 hours | CYP3A4 |
Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015.
- Sildenafil food interactions: High-fat meals can delay its absorption and onset.
- Tadalafil food interactions: Not significantly affected by food intake.
- Vardenafil food interactions: High-fat meals can reduce its absorption and effectiveness.
- Avanafil food interactions: Can be taken with or without food.
- Alcohol interactions: Can increase side effects like dizziness and lower blood pressure.
- Grapefruit juice: Can interact with many medications, including some PDE5 inhibitors.
- Nitrate interactions: Absolute contraindication with any form of organic nitrates.
- Alpha-blocker interactions: Can cause additive blood pressure-lowering effects.
- Antifungal interactions: Drugs like ketoconazole can increase levels of PDE5 inhibitors.
- HIV protease inhibitor interactions: Can significantly increase levels of PDE5 inhibitors.
^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024.
Counseling for Erectile Dysfunction
Journal of the American College of Cardiology. ^ "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses". Archived from the original on 12 July 2018. "Young men add Viagra to their drug arsenal". Archived from the original on 4 September 2014. "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016.